Chloroformic acid methyl
Methyl chloroformate
CAS: 79-22-1
Molecular Formula: C2H3ClO2
Chloroformic acid methyl - Names and Identifiers
Chloroformic acid methyl - Physico-chemical Properties
| Molecular Formula | C2H3ClO2 |
| Molar Mass | 94.5 |
| Density | 1.223g/mLat 25°C(lit.) |
| Melting Point | -61°C |
| Boling Point | 70-72°C(lit.) |
| Flash Point | 64°F |
| Water Solubility | hydrolysis |
| Solubility | Chloroform, Ethyl Acetate |
| Vapor Presure | 4.8 psi ( 20 °C) |
| Vapor Density | 3.26 (vs air) |
| Appearance | Liquid |
| Color | Clear colorless to light yellow |
| Odor | Acrid. |
| Merck | 13,6071 |
| Storage Condition | Store at 0-5°C |
| Stability | Moisture Sensitive |
| Refractive Index | n20/D 1.387(lit.) |
| Physical and Chemical Properties | Colorless transparent liquid with pungent odor. Miscible with ethanol and ether, soluble in benzene and chloroform, slightly soluble in water. |
Chloroformic acid methyl - Risk and Safety
| Risk Codes | R11 - Highly Flammable R21/22 - Harmful in contact with skin and if swallowed. R26 - Very Toxic by inhalation R34 - Causes burns |
| Safety Description | S14 - Keep away from ... (a list of incompatible materials will follow). S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S63 - S46 - If swallowed, seek medical advice immediately and show this container or label. S28A - S39 - Wear eye / face protection. S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 1238 6.1/PG 1 |
| WGK Germany | 2 |
| RTECS | FG3675000 |
| FLUKA BRAND F CODES | 10-19-21 |
| HS Code | 29151300 |
| Hazard Class | 6.1(a) |
| Packing Group | I |
Chloroformic acid methyl - Nature
Open Data Verified Data
colorless transparent liquid with pungent odor. It has tear-inducing effect. Highly toxic, flammable, corrosive. The relative density was 1. 2231. Boiling point 71. Refractive index 3865. Flash point 17 °c. It is miscible with ethanol and ether, soluble in benzene and chloroform, slightly soluble in water, and gradually decomposed by water.
Last Update：2024-01-02 23:10:35
Chloroformic acid methyl - Preparation Method
Open Data Verified Data
methanol and phosgene are esterified, and the obtained esterified liquid is washed with water to remove impurities and then distilled to obtain a finished product. The phosgene system uses Coke to generate carbon monoxide and then reacts with chlorine.
Last Update：2022-01-01 10:33:11
Chloroformic acid methyl - Use
Open Data Verified Data
pesticide raw materials, for the preparation of herbicide herbicide, fungicide carbendazim and so on. It is also a medical raw material, and has been used to produce tear gas in the past.
Last Update：2022-01-01 10:33:11
Chloroformic acid methyl - Safety
Open Data Verified Data
- This product is highly toxic, rat oral LD50< 50mg/kg. It has a strong stimulating effect on the respiratory tract and eye mucosa, when its concentration is up to 52. 8mg/m3, it can cause tears. The maximum allowable concentration in air is 5mg/m3. The operation site should be well ventilated and strictly prevented from running and dripping. Operators should wear protective gear.
- the iron drum is lined with plastic bags or plastic barrels. According to the provisions of toxic and flammable dangerous goods storage and transportation.
Last Update：2022-01-01 10:33:11
Chloroformic acid methyl - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Application | used as an intermediate in organic synthesis, and used in pesticide industry for the preparation of herbicide, herbicide, carbendazim, etc, it is also a pharmaceutical raw material and a lacrimal agent methyl chloroformate is an intermediate of bactericide carbendazim, benomyl and thiophanate-methyl. pesticide raw materials, in order to use the preparation of herbicide herbicide, bactericide carbendazim and so on. It is also a medical raw material, and has been used to produce tear gas in the past. |
| production method | It is industrially obtained by esterification of methanol with phosgene. In batch production, phosgene is introduced into methanol, and the reaction is stirred in a glass-lined reaction pot. This process has low production capacity, high consumption of raw materials and poor product quality. A continuous process is used for mass production. The continuous process generally adopts a glass-lined reaction Tower, first adding methanol in the tower, controlling the reaction temperature to 20-30 ℃, then passing methanol and Phosgene from the bottom of the tower in the same direction, and the content of methyl chloroformate is 93%, the yield was 94%. The tail gas of the reaction was collected by a condenser. A large amount of heat is exothermic in the process of phosgenation, and the reaction is generally controlled to proceed at about 25 ° C by jacket cooling in the reaction Tower. About 400kg of methanol and about 1500kg of phosgene are consumed per ton of methyl chloroformate produced. The preparation method is derived from the reaction of methanol and phosgene. The process is carried out in a reaction column where methanol enters the esterification column from one side of the bottom of the esterification column and phosgene enters the esterification column from the other side, keeping the molar ratio of phosgene to methanol at (1.05-1.1): 1, when the reaction temperature is 35~40 ℃, the content of methyl chloroformate in the synthesis solution is more than 90%, and the yield can reach more than 90%. Reaction equation: CH3OH + COCl2 → ClCOOCH3 + HCl if the molar ratio of methanol is slightly larger, dimethyl carbonate may be formed. In addition, in order to obtain the product of methyl chloroformate, the reaction solution was cooled to room temperature, and the remaining phosgene was removed with nitrogen to destroy the tail gas. |
| category | flammable liquid |
| toxicity grade | high toxicity |
| Acute toxicity | oral-rat LD50: 60 mg/kg; Oral-mouse LD50: 67 mg/kg |
| flammability hazard characteristics | in case of open flame, high temperature, flammable oxidant; Toxic chloride smoke generated by combustion; High thermal decomposition of toxic phosgene; |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored separately from the oxidant |
| extinguishing agent | dry powder, dry sand, carbon dioxide, foam, 1211 extinguishing agent |
| Occupational Standard | TWA 4.4 mg/m3 |
| spontaneous combustion temperature | 485°C |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
